Jul
30
2010
Discovery Of Diabetes
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Stewart-Haas Racing Bike $1.99 … |
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Staff, Staff, Staff $1.99 … |
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Second Trimester … |
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Over the Counter Natural Cures: Take Charge of Your Health in 30 Days with 10 Lifesaving Supplements for under $10 $10.34 Pay Less. Live Healthier. Stop Taking Worthless Prescription Drugs and Overhyped Supplements that Sabotage Your Health. Americans are under attack. Obesity, lethargy, diabetes, heart disease, and cancer are ghastly epidemics. Worse, most drugs can make you even more sick! Why is this happening? Because no one tells you the truth: Millions of dollars are made by keeping this forbidden knowledge fro… |
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The Doctors Book of Food Remedies: The Newest Discoveries in the Power of Food to Treat and Prevent Health Problems-From Aging and Diabetes to Ulcers $12.72 … |
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Survival of the Sickest: A Medical Maverick Discovers Why We Need Disease $4.88 Dan Ariely on Survival of the Sickest MIT professor Dan Ariely has become one of the leaders in the growing field of behavioral economics, and his bestselling book debut, Predictably Irrational, has brought his ideas–and his ingenious experiments and charming sense of humor–to a much wider audience. With the simplest of tests (often an auction or a quiz given under a few conditions) he shows ag… |
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A Stroke Of Health $15.99 After riding the weight roller coaster for years, Judith Swartz shares her story of amazing weight loss by eating healthy. When Judith´s husband Bob suffered a serious stroke on Friday, June 13, 2008, she knew that save his life, the high blood pressure and Type 2 Diabetes must be controlled with lifestyle changes. The discovery results for Bob are positive and he continues to recover. Judith quickly saw improvements in her own body including dramatic weight loss and she candidly provides that simple discovery in A Stroke of Health. If you have ever tried to lose weight, you may laugh and cry with the author as she chronicles her struggles and the delight in simple answers. The Food Pyramid with details and a collection of easy recipes are provided. A Stroke of Health also includes Dr. Bob Galloway´s guidance for Thyroid involvement and treatment which has been another bonus for Judith and her husband. More than a guide for healthy eating, the story provides a glimse of this family´s faith, love and strength. |
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A Stroke Of Health $9.99 After riding the weight roller coaster for years, Judith Swartz shares her story of amazing weight loss by eating healthy. When Judith´s husband Bob suffered a serious stroke on Friday, June 13, 2008, she knew that save his life, the high blood pressure and Type 2 Diabetes must be controlled with lifestyle changes. The discovery results for Bob are positive and he continues to recover. Judith quickly saw improvements in her own body including dramatic weight loss and she candidly provides that simple discovery in A Stroke of Health. If you have ever tried to lose weight, you may laugh and cry with the author as she chronicles her struggles and the delight in simple answers. The Food Pyramid with details and a collection of easy recipes are provided. A Stroke of Health also includes Dr. Bob Galloway´s guidance for Thyroid involvement and treatment which has been another bonus for Judith and her husband. More than a guide for healthy eating, the story provides a glimse of this family´s faith, love and strength. |
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Amylin: Physiology and Pharmacology $112.51 By 1994, researchers had progressed toward an understanding of amylin’s function, and its therapeutic utility. Amylin’s physiology has proven to be surprisingly more simple and elegant than originally conceived. Deciphering amylin’s physiology has revealed previously unrecognized mechanisms, fundamental to the control of body weight and fuel homeostasis that are of general physiologic interest, and beyond an interest simply in the peptide itself. The propagation of this knowledge has been hindered by the entanglement of physiologic discovery with the high-risk business of drug development and the challenge of changing the paradigm of diabetes pathophysiology and treatment. Knowledge of amylin’s physiologic role is now mature, and is collected and discussed in the current book.Features:• Includes historical background of amylin the peptide• Provides a current comprehensive treatment of amylin the hormone.• Discusses biological actions of amylin and amylinomimetics • Therapeutic uses of amylinomimetic drugs |
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Biology of Extracellular Molecular Chaperones $145.03 Novartis Foundation Symposium 291The Biology of Extracellular Molecular ChaperonesChair: Péter CsermelyThe heat shock, or cell stress, response was first identified in the polytene chromosomes of Drosophila. This was later related to the appearance of novel proteins within stressed cells, and the key signal stimulating this appearance was identified as the presence of unfolded proteins within the cell. It is now known that this is a key mechanism enabling cells to survive a multitude of physical, chemical and biological stresses.Since the promulgation of the ‘molecular chaperone’ concept as a general cellular function to control the process of correct protein folding, a large number of molecular chaperones and protein folding catalysts have been identified, and it has been recognized that not all molecular chaperones are stress proteins and vice versa. The discovery of molecular chaperones as folding proteins went hand-in-hand with their recognition as potent immunogens in microbial infection. It was subsequently shown that administration of molecular chaperones such as Hsp60, Hsp70 or Hsp90 could inhibit experimental autoimmune diseases and cancer.More recently evidence has accumulated to show that certain molecular chaperones are also present on the surface of cells or in extracellular fluids. A new paradigm is emerging: at least some molecular chaperones are secreted proteins with pro- or anti-inflammatory actions, regulating the immune response in human diseases such as coronary heart disease, diabetes and rheumatoid arthritis. In addition to having direct effects on cells, molecular chaperones can bind peptides and present them to T cells to modulate immune responses. This may be significant in the treatment of cancer.This book brings researchers together to review and discuss:our current knowledge of cell stress response and molecular chaperonesthe changing paradigms of |
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Biomarkers for Psychiatric Disorders $149 Biological markers, as physiological indicators of disease, hold immense promise for diagnostics and clinical drug trials. While for other complex disorders like diabetes and heart disease a limited number of markers are at hand, there are currently no biomarkers available for psychiatric disorders. Here diagnostic tools are restricted to the evaluation of behavioral and clinical phenotypes, a severe limitation for any scientific study. As in any other disease area a major goal is therefore the identification of markers that can categorize subsets of patients in a consistent manner. This will allow a more precise definition of psychiatric disorders and in turn facilitate investigations of the pathophysiology and enhance the ability for patient treatment. Biomarkers for Psychiatric Disorders provides discovery strategies from scientists in academia and pharma and biotech industries. By addressing the various potential uses of psychiatric biomarkers, this edited volume will interest psychiatrists, neuroscientists, and biomedical scientists working in molecular medicine, disease diagnostics, and drug development.Christoph W. Turck is head of the Proteomics and Biomarkers branch at the Max Planck Institute of Psychiatry and holds faculty appointments in the Department of Biochemistry at Ludwig Maximilians University Munich and the International Max Planck Research School for Molecular and Cellular Life Sciences. |
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Breakthrough: Elizabeth Hughes, the Discovery of Insulin, and the Making of a Medical Miracle $24.99 Her father was a former Justice of the Supreme Court, a former New York governor, and a former Secretary of State, but 11-year-old Elizabeth Hughes was still dying. Weighing only forty-five pound, little Liz was fading fast, a victim of juvenile diabetes, an invariably fatal malady at the time. Coming to the rescue are Canadian scientists Frederick Banting and Charles Best, the discoverers of insulin and the heroes of this new book. Thea Cooper and Arthur Ainsberg’s Breakthrough chronicles a medical advance that every parent can now take as granted. A dramatic and heart-gripping story. |
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Breakthrough: Elizabeth Hughes, the Discovery of Insulin, and the Making of a Medical Miracle $9.99 Her father was a former Justice of the Supreme Court, a former New York governor, and a former Secretary of State, but 11-year-old Elizabeth Hughes was still dying. Weighing only forty-five pound, little Liz was fading fast, a victim of juvenile diabetes, an invariably fatal malady at the time. Coming to the rescue are Canadian scientists Frederick Banting and Charles Best, the discoverers of insulin and the heroes of this new book. Thea Cooper and Arthur Ainsberg’s Breakthrough chronicles a medical advance that every parent can now take as granted. A dramatic and heart-gripping story. |
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Breakthrough: Elizabeth Hughes, the Discovery of Insulin, and the Making of a Medical Miracle $8.08 Her father was a former Justice of the Supreme Court, a former New York governor, and a former Secretary of State, but 11-year-old Elizabeth Hughes was still dying. Weighing only forty-five pound, little Liz was fading fast, a victim of juvenile diabetes, an invariably fatal malady at the time. Coming to the rescue are Canadian scientists Frederick Banting and Charles Best, the discoverers of insulin and the heroes of this new book. Thea Cooper and Arthur Ainsberg’s Breakthrough chronicles a medical advance that every parent can now take as granted. A dramatic and heart-gripping story. |
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Cellular Signaling in Health and Disease $159 In today’s world, three great classes of non-infectious diseases – the metabolic syndromes (such as type 2 diabetes and atherosclerosis), the cancers, and the neurodegenerative disorders – have risen to the fore. These diseases, all associated with increasing age of an individual, have proven to be remarkably complex and difficult to treat. This is because, in large measure, when the cellular signaling pathways responsible for maintaining homeostasis and health of the body become dysregulated, they generate equally stable disease states. As a result the body may respond positively to a drug, but only for a while and then revert back to the disease state. Cellular Signaling in Health and Disease summarizes our current understanding of these regulatory networks in the healthy and diseased states, showing which molecular components might be prime targets for drug interventions. This is accomplished by presenting models that explain in mechanistic, molecular detail how a particular part of the cellular signaling web operates properly in health and improperly in disease.The stability of the health- and disease-associated states is dynamic and supported by multiple feedback loops acting positively and negatively along with linkages between pathways. During the past few years an ongoing series of important discoveries have been made that advance our understanding of how the body works and may guide us on how to better deal with these diseases. These include the discovery of chronic inflammation as a causal factor in all of these disease classes, the appearance of reactive oxygen species as a messenger molecule that can act both positively and negatively, the propensity of proteins to misfold into aggregation- and disease-prone forms, and the rise of epigenetics including the emergence of small non-coding RNA with important regulatory functions out of the so-called junk RNA. Chapters are devoted to each of these classes of findings with additional |
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Cellular Signaling in Health and Disease $159 In today’s world, three great classes of non-infectious diseases – the metabolic syndromes (such as type 2 diabetes and atherosclerosis), the cancers, and the neurodegenerative disorders – have risen to the fore. These diseases, all associated with increasing age of an individual, have proven to be remarkably complex and difficult to treat. This is because, in large measure, when the cellular signaling pathways responsible for maintaining homeostasis and health of the body become dysregulated, they generate equally stable disease states. As a result the body may respond positively to a drug, but only for a while and then revert back to the disease state. Cellular Signaling in Health and Disease summarizes our current understanding of these regulatory networks in the healthy and diseased states, showing which molecular components might be prime targets for drug interventions. This is accomplished by presenting models that explain in mechanistic, molecular detail how a particular part of the cellular signaling web operates properly in health and improperly in disease.The stability of the health- and disease-associated states is dynamic and supported by multiple feedback loops acting positively and negatively along with linkages between pathways. During the past few years an ongoing series of important discoveries have been made that advance our understanding of how the body works and may guide us on how to better deal with these diseases. These include the discovery of chronic inflammation as a causal factor in all of these disease classes, the appearance of reactive oxygen species as a messenger molecule that can act both positively and negatively, the propensity of proteins to misfold into aggregation- and disease-prone forms, and the rise of epigenetics including the emergence of small non-coding RNA with important regulatory functions out of the so-called junk RNA. Chapters are devoted to each of these classes of findings with additional |
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Cellular Signaling in Health and Disease $123.23 In today’s world, three great classes of non-infectious diseases – the metabolic syndromes (such as type 2 diabetes and atherosclerosis), the cancers, and the neurodegenerative disorders – have risen to the fore. These diseases, all associated with increasing age of an individual, have proven to be remarkably complex and difficult to treat. This is because, in large measure, when the cellular signaling pathways responsible for maintaining homeostasis and health of the body become dysregulated, they generate equally stable disease states. As a result the body may respond positively to a drug, but only for a while and then revert back to the disease state. Cellular Signaling in Health and Disease summarizes our current understanding of these regulatory networks in the healthy and diseased states, showing which molecular components might be prime targets for drug interventions. This is accomplished by presenting models that explain in mechanistic, molecular detail how a particular part of the cellular signaling web operates properly in health and improperly in disease.The stability of the health- and disease-associated states is dynamic and supported by multiple feedback loops acting positively and negatively along with linkages between pathways. During the past few years an ongoing series of important discoveries have been made that advance our understanding of how the body works and may guide us on how to better deal with these diseases. These include the discovery of chronic inflammation as a causal factor in all of these disease classes, the appearance of reactive oxygen species as a messenger molecule that can act both positively and negatively, the propensity of proteins to misfold into aggregation- and disease-prone forms, and the rise of epigenetics including the emergence of small non-coding RNA with important regulatory functions out of the so-called junk RNA. Chapters are devoted to each of these classes of findings with additional |
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Characterization of Impurities and Degradants Using Mass Spectrometry $110 An in-depth examination of the importance of mass spectrometry in drug discoveryIn spite of the progress made in research and development to combat diseases such as rheumatoid arthritis, HIV/AIDS, Parkinson’s disease, Alzheimer’s disease, diabetes, and high blood pressure, the drug discovery process itself is delayed by labor-intensive, time-consuming methods that come with a significant price tag. The result: only one out of thousands of potential compounds investigated ever becomes a commercial drug.Characterization of Impurities and Degradants Using Mass Spectrometry examines how mass spectrometry (MS) can be applied to improve the drug development process and get drugs approved more quickly. This book looks at spectrometry with an overview of its capabilities, and then guides the reader on techniques as they relate to the analysis of impurities and degradants, showing why these practices hold great significance in advancing the production of pharmaceuticals. In addition, this book includes: Studies involving characterization of process-related impurities (including potential genotoxic impurities) and excipient-related impurities in formulated productsThe current application and future trends in the structural characterization of impurities and degradants in small molecule pharmaceuticals and biologicsStep-by-step approaches and new strategies for solving challenging problems related to pharmaceutical researchCoverage of trace level analysis and identification of genotoxic impuritiesMass spectrometry has become the leading choice in the structural characterization of pharmaceuticals, providing advanced analysis that both general practitioners in pharmaceutical research and specialists in analytical chemistry can expand on with the insightful procedures presented in this book. |
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Characterization of Impurities and Degradants Using Mass Spectrometry $110 An in-depth examination of the importance of mass spectrometry in drug discoveryIn spite of the progress made in research and development to combat diseases such as rheumatoid arthritis, HIV/AIDS, Parkinson’s disease, Alzheimer’s disease, diabetes, and high blood pressure, the drug discovery process itself is delayed by labor-intensive, time-consuming methods that come with a significant price tag. The result: only one out of thousands of potential compounds investigated ever becomes a commercial drug.Characterization of Impurities and Degradants Using Mass Spectrometry examines how mass spectrometry (MS) can be applied to improve the drug development process and get drugs approved more quickly. This book looks at spectrometry with an overview of its capabilities, and then guides the reader on techniques as they relate to the analysis of impurities and degradants, showing why these practices hold great significance in advancing the production of pharmaceuticals. In addition, this book includes: Studies involving characterization of process-related impurities (including potential genotoxic impurities) and excipient-related impurities in formulated productsThe current application and future trends in the structural characterization of impurities and degradants in small molecule pharmaceuticals and biologicsStep-by-step approaches and new strategies for solving challenging problems related to pharmaceutical researchCoverage of trace level analysis and identification of genotoxic impuritiesMass spectrometry has become the leading choice in the structural characterization of pharmaceuticals, providing advanced analysis that both general practitioners in pharmaceutical research and specialists in analytical chemistry can expand on with the insightful procedures presented in this book. |
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Controlling Fluctuations Of Diabetes Blood Glucose, Healing And Preventing Nerve Damage With Baby’s Milk $14.95 This book is based on the author’s personal experience with Type II Diabetes and its effects on her body.After strictly adhering to the recommended regimen of daily blood draws, medication and extreme dietary adjustments over the course of many years, Leonida Lidman still found herself in great physical and emotional pain.It was only with the discovery of baby’s milk and the solution to the sudden fluctuations of blood glucose that she was able to regain much of the physical energy she enjoyed before diabetes afflicted and tortured her body.Intermingling personal observations of her ailments with medical information copied verbatim from books and leaflets given to her at medical appointments, the author gives a thorough overview of the definitions, side effects and treatment options involved in dealing with diabetes. The author hopes readers will come away with a firm understanding of the disasters that diabetes can wreck on the human body, why these side effects occur, and with solutions to potentially live pain-free lives.About the Author:Mrs. Leonida Lidman received an M.A. in Education from the University of The Philippines and an M.S. in Human Resources Management from the New School for Social Research, New School University, Fifth Avenue, New York City, in 1987.She also graduated in 2009 with an advanced writing course from The Long Ridge Writers’ Group School, Long Ridge, West Redding, Connecticut.Her work experiences include being a college instructor in the Philippines; Training Supervisor for Comprehensive Community Health Programs at the University of The Philippines, Bay, Los Baños, Laguna. She also served as Commissioner of the Newark Senior Citizens Commission and Program Coordinator for the Office on Aging, Newark Housing Authority, in Newark New Jersey from 1987 to 1989. She was a City Council President’s awardee for distinguished community service on behalf of the city’s elderly. She has also |
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Controlling Fluctuations of Diabetes Blood Glucose, Healing and Preventing Nerve Damage with Baby’s Milk $9.95 This book is based on the author’s personal experience with Type II Diabetes and its effects on her body.After strictly adhering to the recommended regimen of daily blood draws, medication and extreme dietary adjustments over the course of many years, Leonida Lidman still found herself in great physical and emotional pain.It was only with the discovery of baby’s milk and the solution to the sudden fluctuations of blood glucose that she was able to regain much of the physical energy she enjoyed before diabetes afflicted and tortured her body.Intermingling personal observations of her ailments with medical information copied verbatim from books and leaflets given to her at medical appointments, the author gives a thorough overview of the definitions, side effects and treatment options involved in dealing with diabetes. The author hopes readers will come away with a firm understanding of the disasters that diabetes can wreck on the human body, why these side effects occur, and with solutions to potentially live pain-free lives.About the Author:Mrs. Leonida Lidman received an M.A. in Education from the University of The Philippines and an M.S. in Human Resources Management from the New School for Social Research, New School University, Fifth Avenue, New York City, in 1987.She also graduated in 2009 with an advanced writing course from The Long Ridge Writers’ Group School, Long Ridge, West Redding, Connecticut.Her work experiences include being a college instructor in the Philippines; Training Supervisor for Comprehensive Community Health Programs at the University of The Philippines, Bay, Los Baños, Laguna. Shealso served as Commissioner of the Newark Senior Citizens Commission and Program Coordinator for the Office on Aging, Newark Housing Authority, in Newark New Jersey from 1987 to 1989. She was a City Council President’s awardee for distinguished community service on behalf of the city’s |
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Cross-Pollinations (The Credo Series): The Marriage of Science and Poetry $3.81 A pioneering ethnobotanist, Gary Paul Nabhan credits the arts with sparking unlikely scientific breakthroughs and believes that such “cross-pollination” engenders new forms of expression that are essential to discovery. In this highly readable book, he tells four stories to illustrate this idea. In the first, coping with color blindness in art class leads to his career as a scientist; in the second, ancient American Indian songs, when translated, reveal an understanding of plants and animals that rivals modern research; in the third, a poem inspires an approach to diabetes using desert plants; and in the fourth, a coalition of scientists and artists creates the Ironwood Forest National Monument in the Sonoran Desert. |
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Dana’s Disease: A Father’s Journey into the World of Diabetes $13.39 Dana’s Disease is a father’s revealing discovery of the effects of diabetes from carefree beginning through a three-year journey of suffering, triumph, and personal awakening. |
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Data mining techniques for temporal point processes applied to insurance claims data. $49.99 We explore data mining on databases consisting of insurance claims information. This dissertation focuses on two major topics we considered by way of data mining procedures. One is the development of a classification rule using kernels and support vector machines. The other is the discovery of association rules using the Apriori algorithm, its extensions, as well as a new association rules technique. With regard to the first topic we address the question—can kernel methods using an SVM classifier be used to predict patients at risk of type 2 diabetes using three years of insurance claims data? We report the results of a study in which we tested the performance of new methods for data extracted from the MarketScanRTM database. We summarize the results of applying popular kernels, as well as new kernels constructed specifically for this task, for support vector machines on data derived from this database. We were able to predict patients at risk of type 2 diabetes with nearly 80% success when combining a number of specialized kernels. The specific form of the data, that of a timed sequence, led us to develop two new kernels inspired by dynamic time warping. The Global Time Warping (GTW) and Local Time Warping (LTW) kernels build on an existing time warping kernel by including the timing coefficients present in classical time warping, while providing a solution for the diagonal dominance present in most alignment methods. We show that the LTW kernel performs significantly better than the existing time warping kernel when the times contained relevant information. With regard to the second topic, we provide a new theorem on closed rules that could help substantially improve the time to find a specific type of rule. An insurance claims database contains codes indicating associated diagnoses and the resulting procedures for each claim. The rules that we consider are of the form diagnoses imply procedures. In addition, we introduce a new class of interesting association |
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Data mining techniques for temporal point processes applied to insurance claims data. $49.99 We explore data mining on databases consisting of insurance claims information. This dissertation focuses on two major topics we considered by way of data mining procedures. One is the development of a classification rule using kernels and support vector machines. The other is the discovery of association rules using the Apriori algorithm, its extensions, as well as a new association rules technique. With regard to the first topic we address the question—can kernel methods using an SVM classifier be used to predict patients at risk of type 2 diabetes using three years of insurance claims data? We report the results of a study in which we tested the performance of new methods for data extracted from the MarketScanRTM database. We summarize the results of applying popular kernels, as well as new kernels constructed specifically for this task, for support vector machines on data derived from this database. We were able to predict patients at risk of type 2 diabetes with nearly 80% success when combining a number of specialized kernels. The specific form of the data, that of a timed sequence, led us to develop two new kernels inspired by dynamic time warping. The Global Time Warping (GTW) and Local Time Warping (LTW) kernels build on an existing time warping kernel by including the timing coefficients present in classical time warping, while providing a solution for the diagonal dominance present in most alignment methods. We show that the LTW kernel performs significantly better than the existing time warping kernel when the times contained relevant information. With regard to the second topic, we provide a new theorem on closed rules that could help substantially improve the time to find a specific type of rule. An insurance claims database contains codes indicating associated diagnoses and the resulting procedures for each claim. The rules that we consider are of the form diagnoses imply procedures. In addition, we introduce a new class of interesting association |
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Defining Optimal Immunotherapies for Type 1 Diabetes: Novartis Foundation Symposium $134.93 Type 1 diabetes (T1D) can be managed by administration of insulin, but the search continues for a more permanent cure.  Hopes were high in the early 1990s, when the similarity between mouse and human MHC class II diabetes susceptibility genes had been discovered, and a cure seemed at hand via modulating interactions between CD4+ T cells and such MHC molecules. Unfortunately pathogenesis of T1D is much more complex, polygenic, dependent on disease penetrance on multiple environmental factors, and likely to involve the participation of CD4+, CD8+ and B lymphocytes. Additionally, islet β-cell destruction might involve mechanisms that differ among individuals.Since T1D is an autoimmune disease, a likely strategy in this search for a cure seems to be modulation of the immune system. This book therefore brings together contributions from leaders in the arena of clinical immunotherapy, not limited to the diabetes field.Topics discussed focus on the following questions:When and where does the co-ordination of the immune responses leading to islet destruction take place?What are the crucial histopathological features of human diabetes, and are these accurately reflected in mouse models?Can we define the functional features of pathogenic response, and can we assess whether these allow prediction of T1D development on an individual basis?Can we delineate a roadmap for successfully prioritizing and accelerating immunotherapeutics in T1D?Defining optimal immunotherapies for type 1 diabetes offers a comprehensive and up-to-date account of immunological strategies for preventing or treating T1D, and will be of particular interest to diabetologists and endocrinologists, both clinicians and  researchers, as well as to immunologists and molecular or cell biologists and drug discovery scientists. The book also considers T1D within the broader context of autoimmune disease, and is therefore |
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Diabetes Rising: How a Rare Disease Became a Modern Pandemic, and What to Do About It $12.99 Nearly 90 years after the discovery of insulin, with an estimated $116 billion spent annually on the medical treatment of diabetes in the United States, why is diabetes the one major cause of death that’s been relentlessly rising for a century? Diabetes Rising investigates why the nearly two dozen medications approved for type 2 (adult-onset) diabetes, and all the high-tech treatments for type 1 (juvenile-onset) diabetes, are failing to slow this modern pandemic of Western civilization. The book also profiles promising new approaches that are making significant strides toward preventing, curing, or dramatically improving treatment of the disease. Written by Dan Hurley, a regular contributor to the science section of the New York Times (and himself a type 1 diabetic for over 30 years), Diabetes Rising breaks medical news by revealing:The wealthiest town in Massachusetts, where an outbreak of type 1 diabetes among the children has parents up in arms, and a state investigation underway.The county in West Virginia with the highest rate of type 2 diabetes in the country (where Hurley spent an evening with a family of 10 siblings, all of whom have the disease, and the local Wal-Mart proudly announces that it sells more Little Debbie snack cakes than any other Wal-Mart in the world). Why the rate of type 1 diabetes has been rising just as fast and just as long as the rate of type 2, transforming a childhood disease that was once exceedingly rare into one that now affects most elementary school systems in the country. How the “artificial pancreas,” long considered a holy grail that would take decades to develop, has now reached the final stages of testing—the book describes Hurley’s extraordinary experience participating in one of the world’s first clinical trials of the device, and profiles the colorful mavericks pushing the technology forward. Why international |
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Diabetes: The Biography $24.95 Diabetes is a disease with a fascinating history and one that has been growing dramatically with urbanization. According to the World Health Authority, it now affects 4.6% of adults over 20, reaching 30% in the over 35s in some populations. It is one of the most serious and widespread diseases today. But the general perception of diabetes is quite different.At the beginning of the 20th century, diabetes sufferers mostly tended to be middle-aged and overweight, and could live tolerably well with the disease for a couple of decades, but when it occasionally struck younger people, it could be fatal within a few months. The development of insulin in the early 1920s dramatically changed things for these younger patients. But that story of the success of modern medicine has tended to dominate public perception, so that diabetes is regarded as a relatively minor illness. Sadly, that is far from the case, and diabetes can produce complications affecting many different organs.Robert Tattersall, a leading authority on diabetes, describes the story of the disease from the ancient writings of Galen and Avicenna to the recognition of sugar in the urine of diabetics in the 18th century, the identification of pancreatic diabetes in 1889, the discovery of insulin in the early 20th century, the ensuing optimism, and the subsequent despair as the complexity of this now chronic illness among its increasing number of young patients became apparent. Yet new drugs are being developed, as well as new approaches to management that give hope for the future.Diabetes affects many of us directly or indirectly through friends and relatives. This book gives an authoritative and engaging account of the long history and changing perceptions of a disease that now dominates the concerns of health professionals in the developed world.Diabetes: the biography is part of the Oxford series, Biographies of Diseases, edited by William and Helen Bynum. In each individual |
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Dirty Electricity $9.99 When Thomas Edison began wiring New York City with a direct current electricity distribution system in the 1880s, he gave humankind the magic of electric light, heat, and power; in the process, though, he inadvertently opened a Pandora’s Box of unimaginable illness and death. Dirty Electricity tells the story of Dr. Samuel Milham, the scientist who first alerted the world about the frightening link between occupational exposure to electromagnetic fields and human disease. Milham takes readers through his early years and education, following the twisting path that led to his discovery that most of the twentieth century diseases of civilization, including cancer, cardiovascular disease, diabetes, and suicide, are caused by electromagnetic field exposure. Dr. Milham warns that because of the recent proliferation of radio frequency radiation from cell phones and towers, terrestrial antennas, Wi-Fi and Wi-max systems, broadband internet over power lines, and personal electronic equipment, we may be facing a looming epidemic of morbidity and mortality. In Dirty Electricity, he reveals the steps we must take, personally and as a society, to coexist with this marvelous but dangerous technology. |
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Dirty Electricity: Electrification and the Diseases of Civilization $15.34 When Thomas Edison began wiring New York City with a direct current electricity distribution system in the 1880s, he gave humankind the magic of electric light, heat, and power; in the process, though, he inadvertently opened a Pandora’s Box of unimaginable illness and death.Dirty Electricity tells the story of Dr. Samuel Milham, the scientist who first alerted the world about the frightening link between occupational exposure to electromagnetic fields and human disease. Milham takes readers through his early years and education, following the twisting path that led to his discovery that most of the twentieth century diseases of civilization, including cancer, cardiovascular disease, diabetes, and suicide, are caused by electromagnetic field exposure.Dr. Milham warns that because of the recent proliferation of radio frequency radiation from cell phones and towers, terrestrial antennas, Wi-Fi and Wi-max systems, broadband internet over power lines, and personal electronic equipment, we may be facing a looming epidemic of morbidity and mortality. In Dirty Electricity, he reveals the steps we must take, personally and as a society, to coexist with this marvelous but dangerous technology. |
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Frederick Banting and the Discovery of Insulin $25.7 Recounts the life of the Canadian doctor and how his research led to the discovery of insulin and a treatment for diabetes. |
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Hermann Goldschmidt $46.99 High Quality Content by WIKIPEDIA articles! Hermann Mayer Salomon Goldschmidt (June 17, 1802 – April 26, 1866) was a German-French astronomer and painter who spent much of his life in France. He started out as a painter, but after attending a lecture by the famous French astronomer Urbain Le Verrier turned to astronomy. His discovery of the asteroid Lutetia in 1852 was followed by further findings and by 1861 Goldschmidt had discovered 14 asteroids. He received the Gold Medal of the Royal Astronomical Society in 1861 for having discovered more asteroids than any other person up to that time. He died from complications of diabetes. |
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Hormesis: A Revolution in Biology, Toxicology and Medicine $102.24 Hormesis is defined as any circumstance in which exposure of a cell or organism to a low dose of a substance or condition results in an adaptive stimulatory/beneficial outcome, while exposure to a high dose results in an inhibitory / detrimental outcome. When plotted on a graph the shape of the dose response curve is biphasic, the hallmark of hormesis. This groundbreaking book “Hormesis: A Revolution in Biology, Toxicology and Medicine” describes why and how hormesis is a fundamental feature of all living systems and is based on the evolutionary principle of selection for genetic traits that confer the ability to respond adaptively to adverse environmental conditions. Using numerous specific examples the authors explain why knowledge of hormesis is important for our health, our environment, and the future of our planet. Several chapters of the book describe emerging research findings that elucidate the molecular and cellular underpinnings of the biphasic dose response/hormesis. The implications of the tapping of cellular systems that underlie hormesis for the discovery and optimization of new drugs and dietary formulations are described. From environmental protection policy to medical practice, it is critical that leaders recognize and understand hormesis, and incorporate it into their decision making process. The authors propose that the prevention of major diseases, including diabetes, obesity and cardiovascular disease can be achieved using hormetic approaches. Scientists, physicians, environmental gurus and anyone interested in the science underlying biology and medicine will benefit from reading this book.FeaturesGroundbreaking coverage of an oft experienced, but poorly understood phenomenon that affects all forms of life on earth.Explains why the principle of hormesis is important to our health, our environment, and the future of our planet. Provides specific examples of biphasic dose responses and their |
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In Vivo MR Techniques in Drug Discovery and Development $230 Imaging technologies are receiving much attention in the pharmaceutical industry because of their potential for accelerating drug discovery and development. Magnetic Resonance (MR) Imaging is one of the principal modalities since it allows anatomical, functional, metabolic, and to a certain extent even target-related information to be gathered in vivo at high resolution, favoring the characterization of a disease state and the corresponding drug intervention. The non-invasiveness of MR strengthens the link between preclinical and clinical pharmaceutical research, contributing to improve the characterization of compound effects in early stages of the discovery process in order to increase the chances of success in later phases of drug development. Edited by a leading researcher in MR technology, with contributions from foremost experts in academia and the pharmaceutical industry, this title illustrates the use of MR techniques throughout the drug discovery and development process, from target identification and validation to clinical studies. Numerous chapters focus on individual disease areas, including neurological, cardiac, and pulmonary disorders, cancer studies, diabetes, arthritis, solid organ transplantation, and stem cell-based therapies, showing that different imaging solutions are needed for specific organs. |
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Inflammation in the Pathogenesis of Chronic Diseases: The COX-2 Controversy $143.85 In “Inflammation in the Pathogenesis of Chronic Diseases: The COX-2 Controversy”, a worldwide panel of leading experts discusses the role of inflammation in the pathogenesis of major chronic diseases and the current controversy regarding risk versus benefit of selective cyclooxygenase-2 (COX-2) inhibitors. This volume is intended for scientists in medicine, epidemiology, pharmacology, molecular biology, and related fields. The authors provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future of medicine, including historical perspectives on the discovery and development of aspirin, ibuprofen, and compounds that selectively inhibit COX-2, and the potential for development of new compounds with better efficacy and safety in the 21st century. Specfic chapters illuminate the role of inflammatory mechanisms in the pathogenesis of arthritis, cardiovascular disease, cancer, neurodegenerative disease, diabetes mellitus, obesity, and other life-threatening and debilitating conditions. Experts in cardiovascular medicine explore the “COX-2 controversy” regarding adverse effects of some (not all) selective COX-2 inhibitors on the cardiovasculature. Recent findings suggest that cardiovascular risk associated with some COX-2 inhibitors may not be due to a class effect, but rather depends upon the molecular structure of specific compounds. Important findings are documented in cancer research showing that selective COX-2 inhibitors have powerful antineoplastic effects against major forms of cancer. A special section explores the current evidence supporting the role of COX-2 and inflammation in the development of Alzheimer’s disease and other neurodegenerative conditions and the potential benefit of compounds that modulate COX-2 and other inflammatory cytokines. The final section addresses nutritional modulation of inflammation and the chemopreventive value of anti-inflammatory nutraceutical agents. |
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Inflammation in the Pathogenesis of Chronic Diseases: The COX-2 Controversy $158.96 In “Inflammation in the Pathogenesis of Chronic Diseases: The COX-2 Controversy”, a worldwide panel of leading experts discusses the role of inflammation in the pathogenesis of major chronic diseases and the current controversy regarding risk versus benefit of selective cyclooxygenase-2 (COX-2) inhibitors. This volume is intended for scientists in medicine, epidemiology, pharmacology, molecular biology, and related fields. The authors provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future of medicine, including historical perspectives on the discovery and development of aspirin, ibuprofen, and compounds that selectively inhibit COX-2, and the potential for development of new compounds with better efficacy and safety in the 21st century. Specfic chapters illuminate the role of inflammatory mechanisms in the pathogenesis of arthritis, cardiovascular disease, cancer, neurodegenerative disease, diabetes mellitus, obesity, and other life-threatening and debilitating conditions. Experts in cardiovascular medicine explore the “COX-2 controversy” regarding adverse effects of some (not all) selective COX-2 inhibitors on the cardiovasculature. Recent findings suggest that cardiovascular risk associated with some COX-2 inhibitors may not be due to a class effect, but rather depends upon the molecular structure of specific compounds. Important findings are documented in cancer research showing that selective COX-2 inhibitors have powerful antineoplastic effects against major forms of cancer. A special section explores the current evidence supporting the role of COX-2 and inflammation in the development of Alzheimer’s disease and other neurodegenerative conditions and the potential benefit of compounds that modulate COX-2 and other inflammatory cytokines. The final section addresses nutritional modulation of inflammation and the chemopreventive value of anti-inflammatory nutraceutical agents. |
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Insulin Resistance and Insulin Resistance Syndrome $89.95 Type II diabetes is a disease that has developed into a worldwide epidemic. At the time of the discovery of insulin in the 1920′s there was approximately one Type II patient for every Type I patient. Today, 80 years later, there are close to twenty Type II patients for every Type I patient. Preceding the onset of overt diabetes in most Type II patients is a prolonged period of insulin resistance that entails a host of detrimental derangements including impaired glucose tolerance, dyslipidemia, hypertension and beta cell failure, comprising a disease entity which is best referred to as the ‘Insulin Resistance Syndrome’, or ‘Metabolic Syndrome’. This book deals with the cellular and whole body pathogenic mechanisms and phenotypic expressions in various models of insulin resistance which will be instrumental in improving understanding and development of means for the prevention of the transition from insulin resistance into overt diabetes.Presenting state-of-the-art knowledge in |
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Iron Metabolism $23.6 Purchase includes free access to book updates online and a free trial membership in the publisher’s book club where you can select from more than a million books without charge. Chapters: Hfe Hereditary Hemochromatosis, Iron Deficiency, Ferritin, Iron Deficiency Anemia, Human Iron Metabolism, Transferrin, Iron Overload, Ceruloplasmin, Hemojuvelin, Ferroportin, Hepcidin, Hephaestin, Total Iron-Binding Capacity, Atransferrinemia, Neonatal Hemochromatosis, Serum Iron, Iron Metabolism Disorder, Iron Tests, Hemosiderosis, African Iron Overload, Hemosiderin, Aceruloplasminemia, Juvenile Hemochromatosis, Transferrin Receptor, Haemochromatosis Type 3, Transferrin Saturation, Siderosis, Iron-Binding Proteins. Excerpt: Aceruloplasminemia is an autosomal recessive disorder of iron metabolism characterized by progressive neurodegeneration of the retina and basal ganglia and diabetes mellitus .Iron accumulates in the pancreas , liver and brain . Accumulation in the eye may lead to retinal degeneration . The disease is caused by mutations in the ceruloplasmin gene . Aceruloplasminemia belongs to the group of genetic disorders called neurodegeneration with brain iron accumulation (NBIA).Aceruloplasminemia has an autosomal recessive pattern of inheritance .Websites (URLs online) References (URLs online) See also (online edition) A hyperlinked version of this chapter is at African iron overload , formerly known as “Bantu siderosis “, is an iron overload disorder first observed among people of African descent in Southern Africa .Causes Originally, this was blamed on ungalvanised barrels used to store home-made beer , which led to increased oxidation and increased iron levels in the beer. Further investigation has shown that only some people drinking this sort of beer get an iron overload syndrome, and that a similar syndrome occurred in people of African descent who have had no contact with this kind of beer (e.g., African Americans ). This led investigators to the discovery |
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Mass Spectrometry and Biomarkers Development: Book Issue of Disease Markers $174 One of the major goals of twenty-first century medicine is the identification of biomarkers for the earliest possible stages of disease involvement so that prompt clinical intervention can limit damage, reverse pathological change, and ideally effect a complete cure. New developments in the analytical field of mass spectrometry are providing clinicians and translational scientists with even more powerful tools for the discovery of novel biomarkers. A key requirement for the succesful application of mass spectrometric approaches to biomarker discovery is a clear reference standard for the ‘normal’ human proteome, and a better understanding of the sources and extent of ‘normal’ variability in human plasma proteins. This special issue of Disease Markers includes examples of biomarker discovery efforts directed at breast and prostate cancers, diabetes mellitus, and heart disease. |
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Mechanisms of biosynthesis of the human multicopper oxidase, ceruloplasmin. $49.99 The human multicopper oxidases are part of a family of enzymes that utilize the facile electron chemistry of bound copper ions to catalyze the four-electron reduction of oxygen concomitantly with the oxidation of ferrous (Fe 2+) to ferric (Fe3+) iron. In humans, the multicopper oxidases are ceruloplasmin, which is expressed as a secreted isoform in hepatocytes or as a glycosylphosphatidylinositol-anchored protein expressed mainly in astrocytes, and the homologous type I membrane bound protein, hephaestin. Both ceruloplasmin and hephaestin are critical for maintaining iron homeostasis by enabling iron uptake and efflux. Ceruloplasmin was demonstrated to be essential for iron mobilization by the discovery of the autosomal recessive disorder aceruloplasminemia. Patients with aceruloplasminemia present with diabetes mellitus, retinal degeneration and neurological symptoms due to parenchymal iron accumulation. A number of missense mutations found in patients with aceruloplasminemia were biochemically analyzed and led to the identification of four distinct classes of missense mutations. These mutations revealed that copper incorporation into apoceruloplasmin requires precise folding and quality control in the late secretory pathway. Additionally, holoceruloplasmin synthesis was affected by treatment with the vacuolar ATPase inhibitor bafilomycin, revealing that pH plays a critical role in copper incorporation in vivo. These findings support the concept that copper incorporation into ceruloplasmin is dependent upon both protein structure and the intracellular conditions of the late secretory pathway. Analysis of GPI-anchored ceruloplasmin revealed that the intracellular copper concentration affected the stability of the protein on the cell surface. Furthermore, apoGPI-anchored ceruloplasmin mutants exhibited more rapid cell surface turnover, although trafficking to and localization on the cell surface were unaffected. In addition, these studies indicated that the turnover |
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Mechanisms of biosynthesis of the human multicopper oxidase, ceruloplasmin. $49.99 The human multicopper oxidases are part of a family of enzymes that utilize the facile electron chemistry of bound copper ions to catalyze the four-electron reduction of oxygen concomitantly with the oxidation of ferrous (Fe 2+) to ferric (Fe3+) iron. In humans, the multicopper oxidases are ceruloplasmin, which is expressed as a secreted isoform in hepatocytes or as a glycosylphosphatidylinositol-anchored protein expressed mainly in astrocytes, and the homologous type I membrane bound protein, hephaestin. Both ceruloplasmin and hephaestin are critical for maintaining iron homeostasis by enabling iron uptake and efflux. Ceruloplasmin was demonstrated to be essential for iron mobilization by the discovery of the autosomal recessive disorder aceruloplasminemia. Patients with aceruloplasminemia present with diabetes mellitus, retinal degeneration and neurological symptoms due to parenchymal iron accumulation. A number of missense mutations found in patients with aceruloplasminemia were biochemically analyzed and led to the identification of four distinct classes of missense mutations. These mutations revealed that copper incorporation into apoceruloplasmin requires precise folding and quality control in the late secretory pathway. Additionally, holoceruloplasmin synthesis was affected by treatment with the vacuolar ATPase inhibitor bafilomycin, revealing that pH plays a critical role in copper incorporation in vivo. These findings support the concept that copper incorporation into ceruloplasmin is dependent upon both protein structure and the intracellular conditions of the late secretory pathway. Analysis of GPI-anchored ceruloplasmin revealed that the intracellular copper concentration affected the stability of the protein on the cell surface. Furthermore, apoGPI-anchored ceruloplasmin mutants exhibited more rapid cell surface turnover, although trafficking to and localization on the cell surface were unaffected. In addition, these studies indicated that the turnover |
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Membrane Transporters in Drug Discovery and Development: Methods and Protocols $139 Studies of membrane transporters have had a great impact on our understanding of human diseases and the design of effective drugs. In Membrane Transporters in Drug Discovery and Development: Methods and Protocols, expert researchers provide practical methodologies of the ongoing research on membrane transporters, considering applications of transporter technologies in drug discovery and development. Chapters include new and useful fields and methodologies, including pharmacogenomics, nutrigenomics, systems biology, bioinformatics, nuclear magnetic resonance (NMR), imaging, and quantitative real-time-PCR. Transporter studies in drug discovery and development for various diseases are discussed, including neuropsychiatric disorders, cardiovascular diseases, ophthalmic diseases, cancer, and diabetes. Composed in the highly successful Methods in Molecular Biology™ series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls.Wide-ranging and current, Membrane Transporters in Drug Discovery and Development: Methods and Protocols delivers a collection of practical protocols that can be used immediately in the lab, along with critical surveys of key topics by leading researchers in the field. |
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Metabolic Basis of Obesity $219 The obesity epidemic has generated immense interest in recent years due to the wide-ranging and significant adverse health and economic consequences that surround the problem. Much attention has been focused on behaviors that lead to obesity, in particular to over consumption of energy-dense food and to sedentary lifestyle. However, obesity is an extremely complex condition with poorly defined pathogenesis. Thanks to greatly enhanced research in the area, the discovery of pathways in the brain and peripheral organs that mediate energy homeostasis has provided a framework for understanding the biological basis of obesity. Metabolic Basis of Obesity adds an important new dimension to the growing literature on obesity by offering a comprehensive review of specifically how metabolic imbalance culminates in obesity. Developed by a team of expert authors, this important title discusses the principles of energy balance, genetics of body weight regulation, hormones and adipokines, and metabolic pathways in the brain, liver, muscle and fat, to name just several of the areas covered. The book also examines the connection between obesity and diabetes, cardiovascular disease and other complications. Current and future diagnostic and treatment strategies are also reviewed. Comprehensive and timely, Metabolic Basis of Obesity is an essential reference for understanding the burgeoning problem of obesity. |
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Metabolic pathways of type 2 diabetes: Intersection of genetics, transcriptomics, and metabolite profiling. $49.99 Type 2 diabetes is characterized by insufficient insulin secretion to maintain euglycemia in the setting of peripheral insulin resistance. The majority of insulin-resistant diabetics are obese, yet not all insulin-resistant obese individuals develop diabetes. This obesity/diabetes dichotomy suggests that genetic factors play a pivotal role in disease pathogenesis.;Gene mapping has identified genetic quantitative trait loci (QTL) influencing disease-related phenotypes. To uncover molecular pathways leading from genotype to clinical trait, we classify phenotypes in greater depth and identify QTL that influence combinations of physiological traits, mRNA levels, and metabolite abundance. A major challenge then becomes deciphering the causal interrelationships among correlated phenotypes.;In this dissertation, we develop methods for building causal direction into an undirected network by including QTLs for each phenotype. We then apply and validate these methods in an F2 intercross between the diabetes-resistant C57BL/6 leptinob/ob (B6ob/ob ) and the diabetes-susceptible BTBR leptin ob/ob (BTBRob/ob) mouse strains. We show that genomic analysis can be integrated with liver transcriptional and metabolite profiling data to construct causal networks for specific metabolic processes in liver. This causal network construction led to the discovery of a pathway by which glutamine induces Phosphoenolpyruvate carboxykinase (Pck1) expression.;To investigate glutamine induction of Pck1 in the context of diabetes, we perform mRNA expression analysis and metabolic profiling in liver of the parental strains. We find glutamine is decreased with obesity in both strains; in the diabetes-resistant B6 strain, liver Pck1 expression parallels glutamine abundance, but in the diabetessusceptible BTBR strain, Pck1 is elevated with obesity. Follow-up in vitro studies indicate that a-ketoglutarate, which is elevated nearly two fold in the livers of BTBR relative to B6 mice in vivo, may mediate |
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Metabolic pathways of type 2 diabetes: Intersection of genetics, transcriptomics, and metabolite profiling. $49.99 Type 2 diabetes is characterized by insufficient insulin secretion to maintain euglycemia in the setting of peripheral insulin resistance. The majority of insulin-resistant diabetics are obese, yet not all insulin-resistant obese individuals develop diabetes. This obesity/diabetes dichotomy suggests that genetic factors play a pivotal role in disease pathogenesis.;Gene mapping has identified genetic quantitative trait loci (QTL) influencing disease-related phenotypes. To uncover molecular pathways leading from genotype to clinical trait, we classify phenotypes in greater depth and identify QTL that influence combinations of physiological traits, mRNA levels, and metabolite abundance. A major challenge then becomes deciphering the causal interrelationships among correlated phenotypes.;In this dissertation, we develop methods for building causal direction into an undirected network by including QTLs for each phenotype. We then apply and validate these methods in an F2 intercross between the diabetes-resistant C57BL/6 leptinob/ob (B6ob/ob ) and the diabetes-susceptible BTBR leptin ob/ob (BTBRob/ob) mouse strains. We show that genomic analysis can be integrated with liver transcriptional and metabolite profiling data to construct causal networks for specific metabolic processes in liver. This causal network construction led to the discovery of a pathway by which glutamine induces Phosphoenolpyruvate carboxykinase (Pck1) expression.;To investigate glutamine induction of Pck1 in the context of diabetes, we perform mRNA expression analysis and metabolic profiling in liver of the parental strains. We find glutamine is decreased with obesity in both strains; in the diabetes-resistant B6 strain, liver Pck1 expression parallels glutamine abundance, but in the diabetessusceptible BTBR strain, Pck1 is elevated with obesity. Follow-up in vitro studies indicate that a-ketoglutarate, which is elevated nearly two fold in the livers of BTBR relative to B6 mice in vivo, may mediate |
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Metabolic pathways of type 2 diabetes: Intersection of genetics, transcriptomics, and metabolite profiling. $108 Type 2 diabetes is characterized by insufficient insulin secretion to maintain euglycemia in the setting of peripheral insulin resistance. The majority of insulin-resistant diabetics are obese, yet not all insulin-resistant obese individuals develop diabetes. This obesity/diabetes dichotomy suggests that genetic factors play a pivotal role in disease pathogenesis.;Gene mapping has identified genetic quantitative trait loci (QTL) influencing disease-related phenotypes. To uncover molecular pathways leading from genotype to clinical trait, we classify phenotypes in greater depth and identify QTL that influence combinations of physiological traits, mRNA levels, and metabolite abundance. A major challenge then becomes deciphering the causal interrelationships among correlated phenotypes.;In this dissertation, we develop methods for building causal direction into an undirected network by including QTLs for each phenotype. We then apply and validate these methods in an F2 intercross between the diabetes-resistant C57BL/6 leptinob/ob (B6ob/ob ) and the diabetes-susceptible BTBR leptin ob/ob (BTBRob/ob) mouse strains. We show that genomic analysis can be integrated with liver transcriptional and metabolite profiling data to construct causal networks for specific metabolic processes in liver. This causal network construction led to the discovery of a pathway by which glutamine induces Phosphoenolpyruvate carboxykinase (Pck1) expression.;To investigate glutamine induction of Pck1 in the context of diabetes, we perform mRNA expression analysis and metabolic profiling in liver of the parental strains. We find glutamine is decreased with obesity in both strains; in the diabetes-resistant B6 strain, liver Pck1 expression parallels glutamine abundance, but in the diabetessusceptible BTBR strain, Pck1 is elevated with obesity. Follow-up in vitro studies indicate that a-ketoglutarate, which is elevated nearly two fold in the livers of BTBR relative to B6 mice in vivo, may mediate |
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Mouse Models for Drug Discovery: Methods and Protocols $48.5 As the drug discovery process shifts more and more toward specifically targeting pathways and molecules, model systems continue to increase in importance, and the mouse, with its versatility, ease of use, and remarkable similarity to the human genome, has clearly risen to the forefront of animal model studies. In Mouse Models for Drug Discovery: Methods and Prools, experts in the field present some background for those less familiar with mice as experimental model platforms as well as a collection of techniques involving general methods as well as specific disease topics such as type 1 and 2 diabetes, cardiovascular disease, arthritis, skin disorders, cancer, the use of behavioral models for depression and anxiety, neurodegenerative diseases, neuromuscular diseases, and infectious diseases. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory prools, and notes on troubleshooting and avoiding known pitfalls.Authoritative and easy-to-use, Mouse Models for Drug Discovery: Methods and Prools will stimulate those not familiar with the power of the mouse and its potential for the drug discovery process, and it will encourage the development of new models and new ways to utilize existing models in order to further the use of this dynamic animal in this vital field. |
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Nanoswarm – Invasion from Inner Space $13.42 Life in the year 2030 was almost perfect. War, crime, hunger and pollution were history. Just as scientists were on the verge of curing disease, people all over the world started getting sick, and no one knew why. Nanoswarm is based on an action-packed video game that takes tweens on a journey of self-discovery to save a friend – and themselves. Obesity has become one of the leading causes of death, worldwide. The Nanoswarm book and video game are designed as unique approaches to promoting healthy diet and exercise behavior. The project was funded by the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health (NIH). See the video trailer at: www.archimage.com/nanoswarm.cfm |
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Nitric Oxide: Basic Research and Clinical Applications $83 This book deals with mediation by nitric oxide (NO) of many biological functions. Nitric oxide, initially known as Endothelial Derived Relaxing Factor (EDRF, Furchgott, Zawadzki 1980), six years later was identified as nitric oxide. Nowadays, its significance reached clinical applications. Clinical significance of nitric oxide encompasses: a/ application of NO-donors such as nitroglycerin and other organic nitrates or sydnonimines in cardiovascular diseases b/ exploitation of stimulation of nitrergic nerves in bronchial asthma or treatment of male impotence c/ resuscitation of fading endothelial function in diabetes or atherosclerosis by using drugs which stimulate vascular endothelium d/ protection of vascular or cardiac transplants from rejection e/ regulation of renal function f/ management of septic shock patients, and many other applications. Basic research of NO is of utmost importance for its further practical applications. Among the authors of the book there are two Nobel Prize winners, Robert Furchgott and Murad Ferid, in physiology and medicine who received their prize in 1998 for the discovery of biological significance of nitric oxide. This work presents the latest data on: cellular signalling by nitric oxide, structure and activity of nitric oxide synthases, the mode of activation by nitric oxide of soluble guanylate cyclase, the role of formation of peroxynitrites, the mode of inhibition of nitric oxide synthase by drugs, interaction between nitric oxide and other endothelial mediators such as prostacyclin or plasminogen activator, specificity of physiology of isoenzymes of nitric oxide synthase in vascular wall, in brain and in immunological system. Practically, therecent achievements in nitric oxide basic research and therefrom deriving clinical applications – as seen from West and East Europe and the U.S.A. – will all be covered by the chapters of this book. In summary, this book will outline the hottest issues on biology, pharmacology, and |
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Orexin-A and some metabolic hormones $84.99 Orexins, also named hypocretins, are neuropeptides present in the hypothalamus. The orexin signaling pathway thought to participate in a complex cycle of energy homeostasis,many studies have extended the multifaceted role of orexins to the regulation of peripheral functions either through a central control or direct interaction with peripheral target tissues such as hypophysis, adrenals, GIT or endocrine pancreas. Furthermore, pharmacological intervention directed at the orexin receptors may prove to be an attractive avenue toward the discovery of novel therapeutics for diseases involving dysregulation of energy homeostasis such as obesity and diabetes mellitus. This book, therefore, discuss the possible effects of orexin-A on insulin secretion, the hypothalamo- pituitary-adrenal axis function, and the adrenergic system, as regulators of energy homeostasis, this up- to-date analysis should help medical students, postgraduates, and specially researchers in physiology of endocrinology and metabolism. |
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Origins: How the Nine Months Before Birth Shape the Rest of Our Lives $9.99 What makes us the way we are? Some say it’s the genes we inherit at conception. Others are sure it’s the environment we experience in childhood. But could it be that many of our individual characteristics—our health, our intelligence, our temperaments—are influenced by the conditions we encountered before birth? That’s the claim of an exciting and provocative field known as fetal origins. Over the past twenty years, scientists have been developing a radically new understanding of our very earliest experiences and how they exert lasting effects on us from infancy well into adulthood. Their research offers a bold new view of pregnancy as a crucial staging ground for our health, ability, and well-being throughout life.Author and journalist Annie Murphy Paul ventures into the laboratories of fetal researchers, interviews experts from around the world, and delves into the rich history of ideas about how we’re shaped before birth. She discovers dramatic stories: how individuals gestated during the Nazi siege of Holland in World War II are still feeling its consequences decades later; how pregnant women who experienced the 9/11 attacks passed their trauma on to their offspring in the womb; how a lab accident led to the discovery of a common household chemical that can harm the developing fetus; how the study of a century-old flu pandemic reveals the high personal and societal costs of poor prenatal experience. Origins also brings to light astonishing scientific findings: how a single exposure to an environmental toxin may produce damage that is passed on to multiple generations; how conditions as varied as diabetes, heart disease, and mental illness may get their start in utero; why the womb is medicine’s latest target for the promotion of lifelong health, from preventing cancer to reducing obesity. The fetus is not an inert being, but an active and dynamic creature, |
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Origins: How the Nine Months Before Birth Shape the Rest of Our Lives $3.32 What makes us the way we are? Some say it’s the genes we inherit at conception. Others are sure it’s the environment we experience in childhood. But could it be that many of our individual characteristics—our health, our intelligence, our temperaments—are influenced by the conditions we encountered before birth? That’s the claim of an exciting and provocative field known as fetal origins. Over the past twenty years, scientists have been developing a radically new understanding of our very earliest experiences and how they exert lasting effects on us from infancy well into adulthood. Their research offers a bold new view of pregnancy as a crucial staging ground for our health, ability, and well-being throughout life.Author and journalist Annie Murphy Paul ventures into the laboratories of fetal researchers, interviews experts from around the world, and delves into the rich history of ideas about how we’re shaped before birth. She discovers dramatic stories: how individuals gestated during the Nazi siege of Holland in World War II are still feeling its consequences decades later; how pregnant women who experienced the 9/11 attacks passed their trauma on to their offspring in the womb; how a lab accident led to the discovery of a common household chemical that can harm the developing fetus; how the study of a century-old flu pandemic reveals the high personal and societal costs of poor prenatal experience. Origins also brings to light astonishing scientific findings: how a single exposure to an environmental toxin may produce damage that is passed on to multiple generations; how conditions as varied as diabetes, heart disease, and mental illness may get their start in utero; why the womb is medicine’s latest target for the promotion of lifelong health, from preventing cancer to reducing obesity. The fetus is not an inert being, but an active and dynamic creature, |
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Origins: How the Nine Months Before Birth Shape the Rest of Our Lives $5.73 What makes us the way we are? Some say it’s the genes we inherit at conception. Others are sure it’s the environment we experience in childhood. But could it be that many of our individual characteristics—our health, our intelligence, our temperaments—are influenced by the conditions we encountered before birth? That’s the claim of an exciting and provocative field known as fetal origins. Over the past twenty years, scientists have been developing a radically new understanding of our very earliest experiences and how they exert lasting effects on us from infancy well into adulthood. Their research offers a bold new view of pregnancy as a crucial staging ground for our health, ability, and well-being throughout life.Author and journalist Annie Murphy Paul ventures into the laboratories of fetal researchers, interviews experts from around the world, and delves into the rich history of ideas about how we’re shaped before birth. She discovers dramatic stories: how individuals gestated during the Nazi siege of Holland in World War II are still feeling its consequences decades later; how pregnant women who experienced the 9/11 attacks passed their trauma on to their offspring in the womb; how a lab accident led to the discovery of a common household chemical that can harm the developing fetus; how the study of a century-old flu pandemic reveals the high personal and societal costs of poor prenatal experience. Origins also brings to light astonishing scientific findings: how a single exposure to an environmental toxin may produce damage that is passed on to multiple generations; how conditions as varied as diabetes, heart disease, and mental illness may get their start in utero; why the womb is medicine’s latest target for the promotion of lifelong health, from preventing cancer to reducing obesity. The fetus is not an inert being, but an active and dynamic creature, |
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Paradise for Sale: A Parable of Nature $1.25 The grim history of Nauru Island, a small speck in the Pacific Ocean halfway between Hawaii and Australia, represents a largender story of environmental degradation and economic dysfunction. For more than 2,000 years traditional Nauruans, isolated from the rest of the world, lived in social and ecological stability. But in 1900 the discovery of phosphate, an absolute requirement for agriculture, catapulted Nauru into the world market. Colonial imperialists who occupied Nauru and mined it for its lucrative phosphate resources devastated the island, which forever changed its native people. In 1968 Nauruans regained rule of their island and immediately faced a conundrum: to pursue a sustainable future that would protect their truly valuable natural resources—the biological and physical integrity of their island—or to mine and sell the remaining forty-year supply of phosphate and in the process make most of their home useless. They did the latter. In a captivating and moving style, the authors describe how the island became one of the richest nations in the world and how its citizens acquired all the ills of modern life: obesity, diabetes, heart disease, hypertension. At the same time, Nauru became 80 percent mined-out ruins that contain severely impoverished biological communities of little value in supporting human habitation. This sad tale highlights the dire consequences of a free-market economy, a system in direct conflict with sustaining the environment. In presenting evidence for the current mass extinction, the authors argue that we cannot expect to preserve biodiversity or support sustainable habitation, because our economic operating principles are incompatible withtheseactivities. |
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Stem Cell Technologies: Basics and Applications $29.22 Cutting-edge coverage of stem cell biology and applicationsFeaturing contributions from leading global experts, this authoritative volume addresses all major areas of stem cell biology and their potential therapeutic applications. The first part of the book covers embryonic stem cells and contains details on the emerging field of embryonic stem cell-based drug screening platforms. The second part deals with multipotent adult stem cells from different tissue types, and covers unique concepts such as cancer stem cells and tissue engineering-based approaches for designing microenvironments for tissue regeneration. Eighty pages of inserts with 113 color figures are included in this pioneering work.Coverage includes: Zebrafish, medaka, chicken embryonic, and mouse embryonic stem cells Derivation of human embryonic stem cells (hESCs) from blastocysts Treating diabetes with hESCs hESCs as a model system to study human genetics Application of hESCs in drug discovery Adult stem cells for regenerative medicine and cancer therapies Mesenchymal stem cells for neurodegenerative disease therapies Dental pulp, hematopoietic, and spermatogonial stem cells Epigenetic regulators of stem cell pluripotency Cancer stem cells |
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Stem Cells and Cancer $93.12 Significance of Stem Cells to Tumor DevelopmentCancer stem cells remain a controversial topic and the criteria that define cancer stem cells are continuing to evolve. A recent surge in stem cell research has ignited a field of discovery into many human diseases including diabetes, neuropathologies, and cancer. By replacing specific differentiated cells that have either been lost or died, stem cell therapy proves to be a very promising approach to the treatment of many debilitating diseases. Though stem cells may provide therapeutic benefit under certain conditions, they are also often implicated in the initiation, progression, and therapeutic resistance of malignant disease. This first edition of Stem Cells and Cancer is intended to give a current perspective on the role of stem cells in cancer and strategies for novel therapies directed toward tumor stem cells. The current cancer stem cell hypothesis is presented in several chapters with distinctions made between the hierarchical and shastic models of tumor cell development. “Stemness,” self-renewal, pluripotency, clonality, and tumorigenicity are important concepts applied towards defining cancer stem cells. Signaling pathways such as Wnt, Sonic Hedgehog, Notch, and Bmi-1 that are involved in differentiation, proliferation, and survival are implicated in the malignant process. Additional chapters address the identification of cancer stem cell populations through the evaluation of molecular markers such as CD133, CD44, and CD24, for example, or by Hoescht dye exclusion to recognize ‘side populations.’ Mesenchymal and hematopoietic stem cells are described as well as mouse models that are employed to elucidate the properties and functionality of stem cells in cancer and the stem cell niche. This book encompasses a wide variety of human cancers that include but are not limited to leukemia, gliomas, breast, and prostate cancers. Resistance to conventional therapies, genetic versus epigenetic |
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Stem Cells and Cancer $107.73 Significance of Stem Cells to Tumor DevelopmentCancer stem cells remain a controversial topic and the criteria that define cancer stem cells are continuing to evolve. A recent surge in stem cell research has ignited a field of discovery into many human diseases including diabetes, neuropathologies, and cancer. By replacing specific differentiated cells that have either been lost or died, stem cell therapy proves to be a very promising approach to the treatment of many debilitating diseases. Though stem cells may provide therapeutic benefit under certain conditions, they are also often implicated in the initiation, progression, and therapeutic resistance of malignant disease. This first edition of Stem Cells and Cancer is intended to give a current perspective on the role of stem cells in cancer and strategies for novel therapies directed toward tumor stem cells. The current cancer stem cell hypothesis is presented in several chapters with distinctions made between the hierarchical and shastic models of tumor cell development. “Stemness,” self-renewal, pluripotency, clonality, and tumorigenicity are important concepts applied towards defining cancer stem cells. Signaling pathways such as Wnt, Sonic Hedgehog, Notch, and Bmi-1 that are involved in differentiation, proliferation, and survival are implicated in the malignant process. Additional chapters address the identification of cancer stem cell populations through the evaluation of molecular markers such as CD133, CD44, and CD24, for example, or by Hoescht dye exclusion to recognize ‘side populations.’ Mesenchymal and hematopoietic stem cells are described as well as mouse models that are employed to elucidate the properties and functionality of stem cells in cancer and the stem cell niche. This book encompasses a wide variety of human cancers that include but are not limited to leukemia, gliomas, breast, and prostate cancers. Resistance to conventional therapies, genetic versus epigenetic |
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Stem Cells: Scientific Facts and Fiction $39.95 In the past decades our understanding of stem cell biology has increased tremendously. Many types of stem cells have been discovered in tissues of which everyone presumed were unable to regenerate in adults; these include particularly the heart and the brain. There is vast interest in stem cells from biologists and clinicians who see the potential for regenerative medicine and future treatments for chronic diseases like Parkinson, diabetes and spinal cord lesions based on the use of stem cells and entrepreneurs in biotechnology who expect new commercial applications ranging from drug discovery to transplantation therapies.As is often the case in science, many early claims turned out to be different from those expected. Embryonic stem cell therapies have not moved rapidly into clinical practice. Adult stem cells certainly have given certain degrees of success but not nearly to the extent that advocates would have wished for. Some claims of early successes in adult stem cell therapies have not been sustained in double-blinded, randomized clinical trials. Some claims are now close to routine therapy. Some of the claims not supported by evidence have nevertheless reached private clinical practice so that “stem cell tourism” is beginning to reach exaggerated proportions.This book provides the reader background information on stem cells in a clear and well-organized manner. It provides the non-stem cell expert with an understandable review of the history, current state of affairs, and facts and fiction of the promises of stem cells. It distinguishes itself from the multiplicity of websites on the subject of stem cells by being scientifically, politically and ethically neutral, explaining pros and cons for stem cells of every sort with the intention of reaching a wide readership ranging from advanced students and patient advocacy groups to clinicians, specialists and early phase medics in training. By providing the background scientific and social information, it |
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Stem Cells: Scientific Facts and Fiction $79.95 In the past decades our understanding of stem cell biology has increased tremendously. Many types of stem cells have been discovered in tissues of which everyone presumed were unable to regenerate in adults; these include particularly the heart and the brain. There is vast interest in stem cells from biologists and clinicians who see the potential for regenerative medicine and future treatments for chronic diseases like Parkinson, diabetes and spinal cord lesions based on the use of stem cells and entrepreneurs in biotechnology who expect new commercial applications ranging from drug discovery to transplantation therapies.As is often the case in science, many early claims turned out to be different from those expected. Embryonic stem cell therapies have not moved rapidly into clinical practice. Adult stem cells certainly have given certain degrees of success but not nearly to the extent that advocates would have wished for. Some claims of early successes in adult stem cell therapies have not been sustained in double-blinded, randomized clinical trials. Some claims are now close to routine therapy. Some of the claims not supported by evidence have nevertheless reached private clinical practice so that “stem cell tourism” is beginning to reach exaggerated proportions.This book provides the reader background information on stem cells in a clear and well-organized manner. It provides the non-stem cell expert with an understandable review of the history, current state of affairs, and facts and fiction of the promises of stem cells. It distinguishes itself from the multiplicity of websites on the subject of stem cells by being scientifically, politically and ethically neutral, explaining pros and cons for stem cells of every sort with the intention of reaching a wide readership ranging from advanced students and patient advocacy groups to clinicians, specialists and early phase medics in training. By providing the background scientific and social information, it |
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Story of the Discovery of Insulin: the Young Doctors Collection $21.45 Would you like to know how germs were discovered? Who found the first antibiotic? Who first described blood circulation? How scientists discovered DNA, and insulin, etc.?If you are curious, then read this series. These are some of the stories about the most important medical discoveries ever made, which have saved millions and millions of lives. These extraordinary discoveries are not a simple matter of luck or talent; they are the results of tenacious hard work and never-ending curiosity. Like Louis Pasteur said, “Chance favors only the prepared mind.” There are still many medical mysteries awaiting you to solve. You, as a young doctor, can make a difference and can save more lives. This book is about the discovery of a cure for diabetes and insulin. It is also about young people just like yourselves, who never gave up. |
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Synthetic and endogenous small molecules that regulate stem cell fate. $49.99 Given appropriate conditions, stem cells can self-renew for long periods of time while maintaining the ability to differentiate into various functional cell types in the body (Kim et al., 2007). These characteristics not only make stem cells a useful system in which to study tissue and organ development but also give them great potential for regenerative medicine. Given the success of well practiced cell-based therapies (e.g., hematopoietic stem cell transplantation for hematological diseases (Adamkiewicz et al., 2006; Oringanje et al., 2009) and pancreatic islet cell transplantation for type I diabetes (Vaithilingam et al., 2008)), it is conceivable that this approach could be applied to many other serious medical conditions where cells are lost as a result of disease, injury, or aging. Realization of the therapeutic potential of stem cells will require a better understanding of the signaling pathways that control stem cell fate as well as an improved ability to manipulate stem cell proliferation, differentiation, and reprogramming.;Work presented in this dissertation describes our efforts towards expanding our understanding of stem cell biology. Presented is a review of various discovery-based approaches (Zhao et al., 2005), including high throughput chemical approaches and mass spectrometry, in the stem cell field. In chapter two we report the implementation of an unbiased or untargeted high throughput screen to identify a synthetic small molecule (JC12) that induces differentiation of murine embryonic stem cells to Lmx1a-positive dopamine neuron progenitor cells. The progenitor cells generated in the presence of JC12 express the combination of transcription factors (En1, Otx2, Lmx1a, Lmx1b, Msx1 Mash1 and Ngn2) associated with dopamine neurons with midbrain identity. Initial mechanism of action studies suggest that JC12 does not function via the known hedgehog pathway but does involve the inhibition of Wnt signaling. In chapter three we provide evidence for a |
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Synthetic and endogenous small molecules that regulate stem cell fate. $49.99 Given appropriate conditions, stem cells can self-renew for long periods of time while maintaining the ability to differentiate into various functional cell types in the body (Kim et al., 2007). These characteristics not only make stem cells a useful system in which to study tissue and organ development but also give them great potential for regenerative medicine. Given the success of well practiced cell-based therapies (e.g., hematopoietic stem cell transplantation for hematological diseases (Adamkiewicz et al., 2006; Oringanje et al., 2009) and pancreatic islet cell transplantation for type I diabetes (Vaithilingam et al., 2008)), it is conceivable that this approach could be applied to many other serious medical conditions where cells are lost as a result of disease, injury, or aging. Realization of the therapeutic potential of stem cells will require a better understanding of the signaling pathways that control stem cell fate as well as an improved ability to manipulate stem cell proliferation, differentiation, and reprogramming.;Work presented in this dissertation describes our efforts towards expanding our understanding of stem cell biology. Presented is a review of various discovery-based approaches (Zhao et al., 2005), including high throughput chemical approaches and mass spectrometry, in the stem cell field. In chapter two we report the implementation of an unbiased or untargeted high throughput screen to identify a synthetic small molecule (JC12) that induces differentiation of murine embryonic stem cells to Lmx1a-positive dopamine neuron progenitor cells. The progenitor cells generated in the presence of JC12 express the combination of transcription factors (En1, Otx2, Lmx1a, Lmx1b, Msx1 Mash1 and Ngn2) associated with dopamine neurons with midbrain identity. Initial mechanism of action studies suggest that JC12 does not function via the known hedgehog pathway but does involve the inhibition of Wnt signaling. In chapter three we provide evidence for a |
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Ten Years Younger: The Amazing Ten-Week Plan to Look Better, Feel Better, and Turn Back the Clock $15.99 How would you like to look and feel ten years younger in just ten weeks time? Studies show that Americans on the whole are aging faster than ever with conditions like diabetes, cancer, and heart disease occurring increasingly earlier on in life—along with everyday age indicators like wrinkles and love handles. Now, Dr. Steven Masley, former medical director of the prestigious Pritikin Longevity Center® and a pioneer in anti-aging medicine, delivers a breakthrough plan to turn back the clock, inside and out—no matter what your age! Originally featured on the Discovery Channel, the Ten Years Younger Program is designed to combat the roots of accelerated aging. Poor nutrition, toxins in the environment, stress, and exposure to free radicals all make us old before our time, along with a little-known aging culprit: low- and no-carb diets. As Dr. Masley shows, low-carb diets deprive the body of anti-aging phytonutrients and fiber, accelerate osteoporosis, and damage brain cells. So the first secret of turning back time is: Eat your carbs! Each week, Ten Years Younger guides you through an age-busting combination of cutting-edge nutritional choices, relaxation techniques to reduce the aging effects of stress, and simple workouts designed to build lean muscle and trim and tone your body from head to toe. By following the plan for just ten weeks, you will:Achieve significant weight loss—up to twenty-five pounds Boost your energy levels Rejuvenate your skin Enhance brain function Prevent and reverse the onset of diabetes and heart disease Lower your cholesterol and blood pressure Improve sexual vitalityWith tools to help you assess how your body is really aging, weekly shopping lists and meal plans, and over 100 delicious recipes packed with antioxidants and anti-aging nutrients, Ten Years Younger is the healthiest, safest, and fastest way to take off the years—no surgery required! |
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Ten Years Younger: The Amazing Ten-Week Plan to Look Better, Feel Better, and Turn Back the Clock $13.99 How would you like to look and feel ten years younger in just ten weeks time? Studies show that Americans on the whole are aging faster than ever with conditions like diabetes, cancer, and heart disease occurring increasingly earlier on in life—along with everyday age indicators like wrinkles and love handles. Now, Dr. Steven Masley, former medical director of the prestigious Pritikin Longevity Center® and a pioneer in anti-aging medicine, delivers a breakthrough plan to turn back the clock, inside and out—no matter what your age! Originally featured on the Discovery Channel, the Ten Years Younger Program is designed to combat the roots of accelerated aging. Poor nutrition, toxins in the environment, stress, and exposure to free radicals all make us old before our time, along with a little-known aging culprit: low- and no-carb diets. As Dr. Masley shows, low-carb diets deprive the body of anti-aging phytonutrients and fiber, accelerate osteoporosis, and damage brain cells. So the first secret of turning back time is: Eat your carbs! Each week, Ten Years Younger guides you through an age-busting combination of cutting-edge nutritional choices, relaxation techniques to reduce the aging effects of stress, and simple workouts designed to build lean muscle and trim and tone your body from head to toe. By following the plan for just ten weeks, you will:Achieve significant weight loss—up to twenty-five pounds Boost your energy levels Rejuvenate your skin Enhance brain function Prevent and reverse the onset of diabetes and heart disease Lower your cholesterol and blood pressure Improve sexual vitalityWith tools to help you assess how your body is really aging, weekly shopping lists and meal plans, and over 100 delicious recipes packed with antioxidants and anti-aging nutrients, Ten Years Younger is the healthiest, safest, and fastest way to take off the years—no surgery required! |
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The Bittersweetness of Diabetes: My Personal Journey Through Discovery, Recovery, and Overcoming $9.76 Cheryl Lynn Kantzer Crane, Jim Greenwald (Illustrator), Foreword by Scot Brower,Paperback, English-language edition,Pub by Acacia Publishing, Inc. AZ |
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The Discovery of Insulin $4.59 When insulin was discovered in the early 1920s, even jaded professionals marveled at how it brought starved, sometimes comatose diabetics back to life. In this now-classic study, Michael Bliss unearths a wealth of material, ranging from scientists’ unpublished memoirs to the confidential appraisals of insulin by members of the Nobel Committee. He also resolves a longstanding controversy dating to the awarding of the Nobel to F. G. Banting and J. J. R. Macleod for their work on insulin: because each insisted on sharing the credit with an additional associate, medical opinion was intensely divided over the allotment of credit for the discovery. Bliss also offers a wealth of new detail on such subjects as the treatment of diabetes before insulin and the life-and-death struggle to manufacture it. “The definitive history . . . well written, highly readable.”—London Review of Books “The story of insulin’s discovery ought to be a novel . . . but Michael Bliss’s splendid account is just as absorbing as any fiction.”—Isis “Bliss’s excellent account of the insulin story is a rare dissection of the anatomy of scientific discovery, and serves as a model of how rigorous historical method can correct the myths and legends sometimes perpetrated in the scientific literature.”—New Republic “Scrupulously researched and compellingly readable . . . I wholeheartedly recommend it to anyone with an interest in diabetes, medical history, or medical scandal and gossip.”—British Medical Journal  |
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The Discovery of Insulin $30 When insulin was discovered in the early 1920s, even jaded professionals marveled at how it brought starved, sometimes comatose diabetics back to life. In this now-classic study, Michael Bliss unearths a wealth of material, ranging from scientists’ unpublished memoirs to the confidential appraisals of insulin by members of the Nobel Committee. He also resolves a longstanding controversy dating to the awarding of the Nobel to F. G. Banting and J. J. R. Macleod for their work on insulin: because each insisted on sharing the credit with an additional associate, medical opinion was intensely divided over the allotment of credit for the discovery. Bliss also offers a wealth of new detail on such subjects as the treatment of diabetes before insulin and the life-and-death struggle to manufacture it. “The definitive history . . . well written, highly readable.”—London Review of Books “The story of insulin’s discovery ought to be a novel . . . but Michael Bliss’s splendid account is just as absorbing as any fiction.”—Isis “Bliss’s excellent account of the insulin story is a rare dissection of the anatomy of scientific discovery, and serves as a model of how rigorous historical method can correct the myths and legends sometimes perpetrated in the scientific literature.”—New Republic “Scrupulously researched and compellingly readable . . . I wholeheartedly recommend it to anyone with an interest in diabetes, medical history, or medical scandal and gossip.”—British Medical Journal  |
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The Fight to Survive: A Young Girl, Diabetes, and the Discovery of Insulin $9.99 In 1919, when 11-year-old Elizabeth Evan Hughes was first diagnosed with what we now know is Type 1 or juvenile diabetes, the medical community considered it a death sentence. In The Fight to Survive, Caroline Cox weaves the heart-wrenching story of Hughes’ role in a medical discovery that stopped the disease in its tracks—only weeks before her imminent death. The only account of one of the very first patients to be successfully treated with insulin for juvenile diabetes, this book tells two fascinating stories in tandem: that of Hughes’ personal struggle, and the medical detective story that occurred during a time when endocrinology research made significant strides. It was Frederick Banting and John Macleod, doctors and researchers, who were finally able to create a testable version of insulin treatment to save Hughes’ life. She lived until the age of 74, and Banting and Macleod won the Nobel Prize in Medicine for their work. The Fight to Survive draws on primary sources to vividly bring the era to life, including interviews, newspaper reports, and Hughes’ own letters. Readers with an interest in medical history, pathographies, biography, diabetes, and American history will constitute this audience. |
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The Fight to Survive: A Young Girl, Diabetes, and the Discovery of Insulin $3.56 In 1919, when 11-year-old Elizabeth Evan Hughes was first diagnosed with what we now know is Type 1 or juvenile diabetes, the medical community considered it a death sentence. In The Fight to Survive, Caroline Cox weaves the heart-wrenching story of Hughes’ role in a medical discovery that stopped the disease in its tracks—only weeks before her imminent death. The only account of one of the very first patients to be successfully treated with insulin for juvenile diabetes, this book tells two fascinating stories in tandem: that of Hughes’ personal struggle, and the medical detective story that occurred during a time when endocrinology research made significant strides. It was Frederick Banting and John Macleod, doctors and researchers, who were finally able to create a testable version of insulin treatment to save Hughes’ life. She lived until the age of 74, and Banting and Macleod won the Nobel Prize in Medicine for their work. The Fight to Survive draws on primary sources to vividly bring the era to life, including interviews, newspaper reports, and Hughes’ own letters. Readers with an interest in medical history, pathographies, biography, diabetes, and American history will constitute this audience. |
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The G.I. Diet $4.7 It’s the easiest, most satisfying eating plan possible, a New York Times and Wall Street Journal bestselling program that explains how to lose weight permanently without feeling hungry, counting calories, or jeopardizing your health. Based on the Glycemic Index, or G.I., the breakthrough nutritional discovery that measures the speed at which the body digests food and the impact it has on weight and well-being, The G.I. Diet organizes food into color-coded categories according to their G.I. rating. And that’s it. No more guesswork, no more formulas, no more fads. The G.I. Diet guides you to permanent weight loss as well as increased energy and a decreased risk of heart disease, stroke and diabetes. This revised and updated edition includes more comprehensive food lists; inspiring success stories; new tips on dining out; motivational help; plus recipes, snack ideas, a shopping list, and more. |
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The Hershberg Diet $7 Most people, including physicians, nutritionists, and dieticians, recognize only three macronutrients — protein, carbohydrates, and fat. In this book, Dr. Melissa Hershberg shares her revolutionary discovery of the “fourth macronutrient,” which can change how people view food, eating, and nutritional labels forever. The book explains how to eat “hotty” foods — foods that don’t spike blood sugar and insulin levels, but that do keep metabolism elevated while a proper hormonal environment for weight loss is created. And, by eating food high in the fourth macronutrient, readers can eat more food than they did before — even foods high in fat and carbs — and still lose weight. In addition, the program helps lower blood pressure, reduce cholesterol, and prevent diabetes. The Hershberg Diet provides an easy-to-follow four-phase plan, complete with recipes, menu plans, and tips to help readers create an efficient, customizable, error-proof strategy for shedding pounds. |
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The Human Genome: Book of Essential Knowledge $14.95 “Without a doubt, this is the most important, most wondrous map ever produced by humankind.” —President William Jefferson Clinton, speaking on the initial mapping of the human genome. The DNA sequence that comprises the human genome—the genetic blueprint found in each of our cells—is undoubtedly the greatest code ever to be broken. Completed at the dawn of a new millennium, the feat electrified both the scientific community and the general public with its tantalizing promise of new and better treatments for countless diseases, including Alzheimer’s, cancer, diabetes, and Parkinson’s.Yet what is arguably the most important discovery of our time has also opened a Pandora’s box of questions about who we are as humans and how the unique information stored in our genomes can and might be used, making it all the more important for everyone to understand the new science of genomics. In The Curiosity Guide to the Human Genome, Dr. John Quackenbush, a renowned scientist and professor, conducts a fascinating tour of the history and science behind the Human Genome Project and the technologies that are revolutionizing the practice of medicine today. With a clear and engaging narrative style, he demystifies the fundamental principles of genetics and molecular biology, including the astounding ways in which genes function, alone or together with other genes and the environment, to either sustain life or trigger disease.In addition, Dr. Quackenbush goes beyond medicine to examine how DNA-sequencing technology is changing how we think of ourselves as a species by providing new insights about our earliestancestors and reconfirming our inextricable link to all life on earth.Finally, he explores the legal and ethical questions surrounding such controversial topics as stem cell research, prenatal testing, forensics, and cloning, making this volume of The Curiosity Guides series |
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The role of different adipocyte size populations in the mediation of obesity-related insulin resistance and inflammation. $49.99 Insulin resistance, the cause of type 2 diabetes mellitus, is intimately linked to the dysregulation of adipose tissue. Recent decades have witnessed the discovery and characterization of numerous hormones produced by adipocytes, including leptin, adiponectin and resistin, underscoring the endocrine functions of adipose tissue. To better understand the role of the adipocyte in the mediation of obesity-related insulin resistance and inflammation, this study has optimized the primary adipocyte isolation technique to minimize inflammation inherent to the isolation procedure and has analyzed adiponectin levels and insulin sensitivities of various adipocyte size populations both in vitro and ex vivo.;The data described herein suggest that cell size plays an important, but not solitary, role in the regulation of insulin action and adiponectin production. It is possible that obesity-related insulin resistance is associated with the failure of a population of small adipocytes to expand and produce the insulin sensitizing protein hormone, adiponectin. |
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The role of different adipocyte size populations in the mediation of obesity-related insulin resistance and inflammation. $49.99 Insulin resistance, the cause of type 2 diabetes mellitus, is intimately linked to the dysregulation of adipose tissue. Recent decades have witnessed the discovery and characterization of numerous hormones produced by adipocytes, including leptin, adiponectin and resistin, underscoring the endocrine functions of adipose tissue. To better understand the role of the adipocyte in the mediation of obesity-related insulin resistance and inflammation, this study has optimized the primary adipocyte isolation technique to minimize inflammation inherent to the isolation procedure and has analyzed adiponectin levels and insulin sensitivities of various adipocyte size populations both in vitro and ex vivo.;The data described herein suggest that cell size plays an important, but not solitary, role in the regulation of insulin action and adiponectin production. It is possible that obesity-related insulin resistance is associated with the failure of a population of small adipocytes to expand and produce the insulin sensitizing protein hormone, adiponectin. |
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Type I Diabetes: Etiology and Treatment $127.88 The increasing incidence of diabetes worldwide has prompted a rapid growth in the pace of scientific discovery and clinical understanding of this enigmatic disease. In Type 1 Diabetes: Etiology and Treatment, well-recognized physicians and researchers review the latest thinking about the causes of this condition and the best approaches to treating both its acute and chronic complications. The treatment options discussed range from life-threatening diabetic ketoacidosis to contemporary insulin regimens, from open- and closed-loop insulin delivery devices to modern glucose-sensing mechanisms, as well as such daily life issues as nutrition and education. Also discussed are the management of children under the age of five, the special problems of preadolescents and adolescents, diabetic surgery, and pregnancy, along with the treatment and prevention of the long-term vascular complications that produce coronary artery disease, the loss of limbs, end-stage renal disease, and blindness. The authors pay special attention to explaining the molecular basis of diabetes and its complications, as well as to the many recent developments in whole pancreas and islet cell transplantation, including the means for avoiding the rejection of transplanted islets. Authoritative and up-to-date, Type 1 Diabetes: Etiology and Treatment provides all those caring for diabetic patients with a concise, accessible survey of today’s best thinking about the causes, treatment, and management of this complex disease. |
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Type I Diabetes: Etiology and Treatment $21.09 The increasing incidence of diabetes worldwide has prompted a rapid growth in the pace of scientific discovery and clinical understanding of this enigmatic disease. In Type 1 Diabetes: Etiology and Treatment, well-recognized physicians and researchers review the latest thinking about the causes of this condition and the best approaches to treating both its acute and chronic complications. The treatment options discussed range from life-threatening diabetic ketoacidosis to contemporary insulin regimens, from open- and closed-loop insulin delivery devices to modern glucose-sensing mechanisms, as well as such daily life issues as nutrition and education. Also discussed are the management of children under the age of five, the special problems of preadolescents and adolescents, diabetic surgery, and pregnancy, along with the treatment and prevention of the long-term vascular complications that produce coronary artery disease, the loss of limbs, end-stage renal disease, and blindness. The authors pay special attention to explaining the molecular basis of diabetes and its complications, as well as to the many recent developments in whole pancreas and islet cell transplantation, including the means for avoiding the rejection of transplanted islets. Authoritative and up-to-date, Type 1 Diabetes: Etiology and Treatment provides all those caring for diabetic patients with a concise, accessible survey of today’s best thinking about the causes, treatment, and management of this complex disease. |
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World Diabetes Day $60.99 High Quality Content by WIKIPEDIA articles! World Diabetes Day is the primary global awareness campaign of the diabetes mellitus world and is held on November 14 of each year. It was introduced in 1991 by the International Diabetes Federation and the World Health Organization in response to the alarming rise of diabetes around the world. World Diabetes Day is a campaign that features a new theme chosen by the International Diabetes Federation each year to address issues facing the global diabetes community. While the campaigns last the whole year, the day itself marks the birthday of Frederick Banting who, along with Charles Best, first conceived the idea which led to the discovery of insulin in 1922. |
